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Important Warning:

On April 7, 2005, the Food and Drug Administration (FDA) announced that they are asking manufacturers of all prescription nonsteroidal anti-inflammatory drugs (NSAIDs) to revise the drug labeling (package insert) to include a ''boxed'' or serious warning about the potential for increased risk of cardiovascular events (including heart attack and stroke) and serious and potentially life-threatening gastrointestinal (GI) bleeding associated with their use. This information will also state that patients who have just had heart surgery should not take these medications. The FDA is also asking manufacturers of nonprescription (OTC) NSAIDs to include information on the product label about the potential for cardiovascular events and GI bleeding, as well as skin reactions in patients taking these drugs. You should talk to your doctor if you are taking one of these drugs and have any questions or concerns about this new information.

Medication Information

Naprosyn is used to relieve the pain, tenderness, inflammation (swelling), and stiffness caused by gout, arthritis, and other inflammatory conditions. It also is used to relieve other pain, including muscle and menstrual pain and pain after surgery, dental work, or childbirth.

Naprosyn is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should Naprosyn be used?

Naprosyn comes as a regular tablet, an extended-release tablet, and a liquid to take by mouth. It usually is taken twice a day for arthritis, every 8 hours for gout, and once a day (extended-release tablets) or every 6-8 hours (regular tablets) as needed for pain. Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Naprosyn exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Liquid Naprosyn should be shaken well before each use to mix the medication evenly.

If you obtained Naprosyn without a prescription, do not take it for more than 3 days for fever or 10 days for pain without talking to a doctor.

What special precautions should I follow?

Before taking Naprosyn,
  • tell your doctor and pharmacist if you are allergic to Naprosyn, aspirin or other medications for pain or arthritis, or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially aspirin, atenolol (Tenormin), carteolol (Cartrol), cyclosporine (Neoral, Sandimmune), diuretics ('water pills'), labetalol (Normodyne, Trandate), lithium (Eskalith, Lithobid), medications for arthritis or diabetes, methotrexate, metoprolol (Lopressor), nadolol (Corgard), phenytoin (Dilantin), probenecid (Benemid), warfarin (Coumadin), and vitamins. Do not take aspirin or acetaminophen when using Naprosyn unless directed to do so by your doctor.
  • tell your doctor if you smoke or drink large amounts of alcohol and if you have or have ever had liver, heart, or kidney disease; high blood pressure; any stomach problems; or any other gastrointestinal disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Naprosyn, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Naprosyn.
  • you should know that Naprosyn may make you drowsy. Do not drive a car or operate machinery until you know how Naprosyn affects you.
  • remember that alcohol can add to the drowsiness caused by Naprosyn. Do not drink alcohol while taking Naprosyn.
  • What special dietary instructions should I follow?

    Naprosyn may cause an upset stomach. Take Naprosyn with food or milk.

    What should I do if I forget a dose?

    Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    What side effects can Naprosyn cause?

    Although side effects from Naprosyn are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:
    • headache
    • dizziness
    • nervousness
    • upset stomach
    • stomach pain or cramps
    • vomiting
    • constipation
    • diarrhea
    • gas

    If you experience any of the following symptoms, call your doctor immediately:

    • bloody vomit
    • bloody diarrhea or black, tarry stools
    • ringing in the ears
    • blurred vision
    • swelling of hands, feet, ankles, or lower legs
    • skin rash
    • itching

    What storage conditions are needed for Naprosyn?

    Keep Naprosyn in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

    In case of emergency/overdose

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

    What other information should I know?

    Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Naprosyn.

    Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.